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Studies are also underway to assess the efficacy of GLP1s for: Addiction: Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity (Scientific Reports, Nature), Semaglutide for Alcohol Use Disorder (Phase II clinical trial by UNC) Alzheimer's: The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimers disease (Frontiers in Endocrinology) Mental Health & Suicidal Ideation: Most GLP-1 Medications Correlated with a Lower Likelihood of Anxiety and Depression Diagnoses (Epic Research) Alcohol-related liver disease ( Novo Nordisk clinical trial ) Osteoarthritis ( STEP 9 ) Metabolic dysfunction-associated steatohepatitis (MASH): Tirzepatide for Metabolic DysfunctionAssociated Steatohepatitis with Liver Fibrosis This is just the beginning
Semaglutide should be discontinued once pregnancy is confirmed because safety in pregnancy is not established
Semaglutide Interactions BNF
A study at the University of Adelaide looking at ways to trigger release of the gut hormone GLP-1 - the hormone upon which weight-loss drugs are based - previously found that giving a bile acid enema to healthy volunteers triggered release of GLP-1, but had the unintended consequence of causing diarrhea
The most common patient complaints are minor: soreness at injection site, a transient headache, or mild diarrhea
10.1038/nrgastro.2009.148 43
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