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Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization
Benefits: Po
deficiency limits this, causing unmet NADPH demand and hemolysis. Older erythrocytes hemolyze first due to lower G6PD activity. Reticulocytosis follows initial hemolysis, conferring resistance. G6PD Deficiency Role G6PD deficiency impairs NADPH production, the sole RBC source, making cells vulnerable to primaquines oxidative stress
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PMID 11812920
The adverse-event profile is dominated by one system, predictably and mechanistically
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