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2 Materials and methods The Combat-JUDO trial was a 6-month multi-center, randomized, double-blinded, parallel, placebo-controlled trial (clinicaltrials.gov: NCT02794402) comparing once weekly subcutaneous injections of 2 mg exenatide extended release (Bydureon, AstraZeneca, Cambridge, UK) to placebo for the treatment of pediatric obesity (13)

Research suggests supplementation may improve insulin sensitivity

World J Surg 2016

Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli

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It has a multitude of functions including the stimulation of insulin hormone which regulates blood sugar by storing energy, the inhibition of the ghrelin hormone which induces appetite, the stimulation of the sympathetic nervous system to increase energy expenditure and slow the movement of the gastrointestinal tract.[10] Below is a visual representation of the effect of the GLP-1 drug on a multitude of body systems.[13] Essentially, GLP-1 drugs like Ozempic, Wegovy, etc