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Experiments in mice and nematodes ( Caenorhabditis elegans ) showed that modulation of the intracellular levels of -ketoglutarate interfere with gene transcription and longevity [52, 53, 69]

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While Ozempic mimics one hormone, Tirzepatide (Mounjaro/Zepbound) is a twincretin. It mimics both GLP-1 and GIP (Glucose-dependent Insulinotropic Polypeptide)

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