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13.8% in the placebo group had a primary endpoint (hazard ratio, 0.86

Aged mice were divided into control and treatment groups, with the latter receiving intraperitoneal injections of FOXO4-DRI at doses of 0.5 mg/mL and 5 mg/kg every other day for 30 days, while controls received PBS

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These include maintaining good sleep hygiene, engaging in moderate regular exercise (avoiding intense exercise close to bedtime), performing leg stretches or massage, applying hot or cold packs to the legs, and practicing relaxation techniques