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Body Weight Heavier individuals generally require higher absolute doses to achieve the same serum concentration

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For Hereditary B12 Malabsorption If you suffer from Imerslund-Grasbeck disease, your vitamin B12 malabsorption will be treated with hydroxocobalamin injected into the muscle at a dose of 10 mg per day for 10 days followed by monthly injections for life

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However, those whose stomachs do produce intrinsic factor can properly absorb vitamin B12 and benefit from more optimal health