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Phagocytosed photoreceptor outer segments are highly enriched in polyunsaturated fatty acids and are the major source of intracellular ROS generation in RPE 3,4
The sc infusion was necessary because the GLP-1 molecule is cleared extremely rapidly in the body (intravenous (IV) half-life of 1-2 min.) due to the actions of an enzyme, dipeptidyl peptidase 4 (DPP-4), which inactivates the peptide [13]
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For a thorough review of how to inject GLP-1 medications properly, the technique guides also include practical tips for managing the before-and-after logistics
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