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The aggressive titration tail in the 12 mg arm of the Phase 2 trial was strongly associated with higher rates of transient gastrointestinal adverse events, which is why researchers generally favor slower escalation when tolerability is prioritized

Chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol) Reduce the risk of heart attack, stroke, or death in adults with type 2 diabetes and known heart disease

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Additionally, the FDA was evaluating reports of hair loss and suicidal thoughts in patients taking Ozempic, Mounjaro, or Wegovy