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The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation
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A significant drop, say more than 15 points from where you started, or an eGFR that consistently stays below 60, is something your doctor will want to look into
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Martinet A, et al
If you have barely moved on a reasonable dose, that is the conversation about whether a further step up makes sense
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