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Antioxid Redox Signal (2020) 33:35473

The fundamental mechanism is the activation of phase II detoxification enzymes or antioxidase controlled by Nrf2/ARE, including the expression of NAD(P)H quinone dehydrogenase 1 (NQO1), GPX, and superoxide dismutase (SOD) (Truong et al., 2014)

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Once clinical improvement is confirmed, maintenance supplementation of B 12 will generally be needed for life

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