If you are someone who suffers from severe constipation regardless of medications, you may not be a good candidate for GLP-1s
oral semaglutide requires strict conditions Weight loss : Injectable semaglutide (14.9%) exceeds orforglipron (12.4%)
These drugs are part of an emerging class of nutrient-stimulated hormone-based therapeutics that act as incretin mimetics, targeting G-proteincoupled receptors such as GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon, which are crucial in body fat and energy balance regulation
Also, knowing that you don't need to meet the strict BMI requirements might make them your only available option
doi:10.1016/j.heliyon.2020.e05390
Once the oxidative fire is put out, the mitochondria can begin the slow process of repairing their damaged structural components