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Third, as we will detail below (see Potential Pathogenic Mechanisms of Hyperhomocysteinemia), our own work (Durand et al, 1997a) and the work of Lentz et al (1996) and Bellamy et al (1998) give experimental evidence that moderate hyperhomocysteinemia, which leads to vascular dysfunction, might increase the cardiovascular risk independently of other risk factors

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doi: 10.1126/science.abn9257 121

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and [4] had at least one of the following comorbid conditions: coronary artery disease (e.g., history of myocardial infarction), cerebrovascular disease (e.g., prior stroke or transient ischemic attack), symptomatic peripheral artery disease, or chronic kidney disease, defined as an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m

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P =0.05) and in tobacco-exposed MI compared to tobacco-nave MI rats (7753626 vs 3634379

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