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Individuals with active cancer or a history of malignancy should avoid the peptide unless under medical supervision, as effects on tumor growth have not been adequately studied

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Disadvantages involve benefit decline during off periods requiring acceptance of fluctuation, complexity planning and tracking cycles, uncertainty about optimal timing and duration for individual responses, and potential for forgetting to restart after extended breaks

10.1038/s41580-020-00314-w Nat

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The models are standard, the endpoints are measurable, and the reported direction of effect is reasonably consistent across groups