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Meanwhile, liraglutide ameliorated the dysregulation of malondialdehyde (MDA), nitric oxide (NO), SOD, matrix metalloproteinase (MMP)-2 and -9, as well as IL-6 and IL-10 in the sciatic nerve, while pregabalin had less effect on them
TMAO was shown as widely distributed in sea animals [74], with concentration in the tissue increasing proportionally to the depth of the fishes natural environment [75]
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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in the patients treated with semaglutide injection (3%) compared to placebo (1.8%)
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