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N-Acetyl-p-benzoquinone imine (NAPQI), the toxic metabolite of APAP, besides its intrinsic ability to form aspecific chemical adducts with proteins, promotes the excessive accumulation of ROS mostly depleting the GSH pool that it is required for its detoxification

Mastromarino P, Hemalatha R, Barbonetti A, et al

Fortunately, it is also rare, and the vast majority of children affected by it survive

Immune cells adopt a healing profile rather than an attack profile

Characterization of the human Omega class glutathione transferase genes and associated polymorphisms

Tudor, M., Jandric, I., Marovic, A., Gjurasin, M., Perovic, D., Radic, B., Blagaic, A