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The Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF-JAK) /STAT5- CCAAT/enhancer-binding protein (C/EBP) pathway can activate Acod1 to produce itaconate, mediating Nuclear factor erythroid 2related factor 2 (Nrf2)-dependent ferroptosis resistance and maintaining TIN persistence [48]
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J Clin Invest 127:695708
Meaning that although they are losing weight, they may not be receiving what their body needs to promote optimal wellness and physiological functions
Despite promising preclinical results, T2DM clinical trials have shown variable outcomes [141]
By targeting three hormone systems, it creates more powerful effects on appetite, metabolism, and fat burning than medications targeting fewer pathways
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