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In a 12-week randomized clinical trial involving 300 obese adults, participants receiving 1 mg daily of AOD-9604 lost an average of 2.6 kg (approximately 5.7 pounds) compared to 0.8 kg (1.8 pounds) in the placebo group
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Pharmacokinetics and Bioavailability Researchers have characterized the pharmacokinetic properties of 5-Amino-1MQ including its absorption, distribution, and metabolism
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Swallowed 5-Amino-1MQ has to survive gut absorption and a heavy first pass through the liver
Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans
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