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(PubMed) Schoenfeld JD, Sibenaller ZA, Mapuskar KA, et al

Six trials totaling roughly 900 participants are summarized in Stier et al

Roux-en-Y gastric bypass surgery (RYGB) but not sleeve gastric bypass surgery or gastric banding, increases the risk of vitamin B 12 deficiency and requires preventive post-operative treatment with either injected or high-dose oral supplementation

A deficiency or lack of Vitamin B12 is quite common in the over 65s, those diagnosed with pernicious anaemia, and in anyone who follows a vegan, strict vegetarian, or extreme/fad/restricted diet for a long time without taking a B12 supplement or eating fortified foods

supplementation has demonstrated increased maximal oxygen consumption and modest weight loss in meta-analyses of overweight adults