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Similar reductions were seen under the treatment policy estimand
De Leo E, Elmonem MA, Berlingerio SP, Berquez M, Festa BP, Raso R, Bellomo F, Starborg T, Janssen MJ, Abbaszadeh Z, Cairoli S, Goffredo BM, Masereeuw R, Devuyst O, Lowe M, Levtchenko E, Luciani A, Emma F, Rega LR (2020) Cell-based phenotypic drug screening identifies luteolin as candidate therapeutic for nephropathic cystinosis
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What this analysis can and cannot tell you The CAD $72 billion figure is a central estimate from a country-specific model with a sensitivity range of approximately $30-120 billion across the parameters that carry meaningful uncertainty: real-world adherence at population scale, healthcare-savings ramp, real wage growth, and drug-price evolution