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Product scans of the precursors gave characteristic product ion masses, which were attributed to fragmentation of the TPP-moiety of the compounds, enabling detection by LC-MS/MS (Fig

All the above described side effects & symptoms are classed as normal & will subside on their own

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This hypothesis has been confirmed in clinical trials including hypertensive patients that demonstrated an improved blood pressure control (30, 31) and reduction of cardiovascular events (31) when anti-hypertensive drugs have been administered at bedtime

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