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Additionally, the study looked at cardiovascular outcomes as a pre-specified secondary analysis which included a four-point composite endpoint of cardiovascular death, myocardial infarction, stroke, and hospitalization for unstable angina
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We excluded patients with bariatric surgery history and required weight measurements during baseline (90 days pre-treatment), the first year post-treatment (year 1), and the second year post-treatment (year 2), yielding 34,143 semaglutide-treated and 16,034 tirzepatide-treated patients ( Figure S1 )
Combination studies investigating dual amylin/incretin receptor activation are gaining research interest for their potential synergistic metabolic effects
