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Mitochondrial metabolism and cancer
CAMP response element-binding protein1 (CREB1) and c-Met could take part in miR-433-mediated inhibition of the EMT by regulating Akt/GSK-3/Snail signaling
They also highlight a recurring pattern in peptide drug development: early safety signals, particularly those observed at supraphysiologic exposure levels or in non-human models, have frequently led to premature abandonment of otherwise biologically compelling targets
Measured Liver-fat change, as a percentage of each person's starting level
doi: 10.1091/mbc.e08-02-0138
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