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Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15
It has also been suggested that the presence of Phascolarctobacterium may be implicated in the development of Hashimotos thyroiditis, althought more research is needed in this space
Fathizadeh, H
Birsoy, K
recommend larger-scale studies with long-term follow-up to evaluate possible adverse effects
The evidence base for their use in weight management remains very limited, and their use falls outside the scope of standard NHS prescribing
