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Liver histological endpointsspecifically, resolution of MASH without worsening of fibrosis, and improvement in liver fibrosis by one or more stage without worsening of MASHare considered appropriate intermediate/surrogate endpoints in regulatory and reimbursement settings, based on current regulatory guidelines

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The colon naturally forms small outpouchings (diverticula) as part of aging and genetic predisposition, particularly in people with low-fiber intake or connective tissue variations

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However, the independent effect of exercise on liver histology in NAFLD remains unclear

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