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Glucagon like peptide-1 receptor agonists represent a novel class of anti-hyperglycemic agents that have a cardiac-friendly profile, preserve neuronal cells and inhibit neuronal degeneration, an anti-inflammatory effect in liver protecting it against steatosis, increase insulin sensitivity, promote weight loss, and increase satiety or anorexia
These compounds synergistically work together to unlock various health benefits
Preproglucagon is a 160-amino acid precursor encoded by the GCG gene and expressed in pancreatic -cells, intestinal cells
But actually, the first GLP-1 drug was approved by the Food and Drug Administration (FDA) to treat type 2 diabetes back in 2005
doi: 10.1371/journal.pone.0049062 86
These cardiometabolic improvements matter because excess weight drives many of these risk factors
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