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Inhibition of the plasma membrane L-type Ca 2+ channels results in reduced intracellular Ca 2+ concentration which reduces the capacity to activate myosin light chain kinase, a key enzyme in the contractile activity of smooth muscle

The glucagon component is what sets it apart it increases the body's energy expenditure rather than only suppressing appetite

These symptoms are typically mild to moderate in intensity and tend to be most pronounced during the first few weeks of treatment or when doses are increased

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Individualized risk assessment, patient education, and prompt evaluation of persistent symptoms are essential to optimize treatment adherence and minimize potential clinical and economic consequences