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10.3389/fendo.2023.1142644 56 MaedaE.KawamuraR.SuzukiT.MatsumotoT

For larger vials you can use up to 5 mL more bac water makes microdosing easier, but insulin needles usually max out at 1 mL per injection

For example, exosomal circUSP7 from NSCLC cells inhibits miR-934 in CD8 T cells, upregulates SHP2, suppresses effector cytokine secretion (e.g., TNF-, IFN-), and induces T-cell exhaustion, thereby impairing anti-PD-1 efficacy

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