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Histopathological analyses frequently demonstrate myocardial fibrosis, vascular inflammation, and focal necrosis, indicating maladaptive cardiac remodelling (72)

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Indeed, dulaglutide shows sex-specific treatment differences, as males reduce their intake levels more than females, and the treatment effect persists after discontinuation in males but not in females ( Although these initial studies directly manipulate GLP-1R or GLP-1, other ways to influence the GLP-1 pathway are less studied