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FXR agonists, such as obeticholic acid (OCA), have demonstrated robust efficacy in non-alcoholic steatohepatitis (NASH) by suppressing hepatic de novo lipogenesis through small heterodimer partner (SHP)-mediated inhibition of sterol regulatory element-binding protein 1c (SREBP-1c), while simultaneously enhancing insulin sensitivity and reducing pro-inflammatory cytokine production

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MOTS-c, metformin, and berberine affect AMPK through different paths