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Retatrutide adds glucagon receptor activation for potentially greater fat loss Clinical trials show retatrutide achieving 24.2% weight loss at 48 weeks vs tirzepatide's 20.9% at 72 weeks Tirzepatide (Mounjaro/Zepbound) is FDA-approved and available now

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Glutathione participates in phase II detoxification by GST-mediated conjugation of electrophiles such as drugs, heavy metals, and lipid peroxides forming mercapturates that are eliminated via MRP/ABCC transporters