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Gastrointestinal tolerability and weight reduction associated with tirzepatide in adults with obesity or overweight with and without type 2 diabetes in the SURMOUNT-1 to -4 trials

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The distinction matters because the solution is straightforward: maintain adequate hydration, especially during periods of gastrointestinal distress

Clinical studies show that most patients lose between 510% of baseline body weight within 12 weeks, though some notice changes as early as week one

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