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doi: 10.1074/jbc.M110244200 32 Guerrero-BeltrnCECaldern-OliverMPedraza-ChaverriJChirinoYI
TB-500 (Malinda et al., 1999): Cell migration via LKKTET actin-binding domain
Zinellu A, Mangoni AA
Elevated plasma carnitine levels likely inhibit endogenous production by suppressing -butyrobetaine hydroxylase, the enzyme which converts BB to carnitine (5), therefore leading to an accumulation of BB
All the above evidences seem to have a clinical relevance: Polonikov, studying four moderate-severe COVID-19 cases, found that while the three patients with normal/high plasma levels of GSH recovered rapidly, the one with low GSH levels, high plasma ROS and ROS/GSH ratio experienced the most severe illness and, at the date of publication, was still sick (Polonikov, 2020)
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