Data represent the average of 3 independent experiments performed in triplicate
Although the degradation of glutathione contributes to the cysteine pool, the resulting levels are not sufficient for normal metabolism upon cystine scarcity
TB-500 is a synthetic fragment of Thymosin Beta-4, more often studied in cell-migration and soft-tissue models
Acquisition of 1 H-NMR spectra and metabolic profiling The lyophilized metabolic extracts were suspended in 0.6 ml of deuterated water (Cambridge Isotope Laboratories Inc., Tewksbury, MA, USA) containing phosphate buffer (100 mM) and TSP (3-3-(trimethylsilyl)-2,2,3,3-tetradeuteropropionic acid or TMSP- d 4 , Cambridge Isotope Laboratories) (0.5 mM) and inserted into a 5 mm NMR tube for immediate acquisition
NHS and NICE guidance does not currently recommend glutathione supplementation for fatty liver disease
Lower glutathione means duller skin and slower repair