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Another sirtuin, SIRT7, has been studied in relation to age-related mitochondrial stress
It directly neutralizes reactive oxygen species (ROS) generated by the mitochondrial respiratory chain, regenerates oxidized vitamins C and E, and catalyzes the conjugation of xenobiotics via glutathione S-transferase (phase II detoxification)
The patient data are presented in Table 1
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Purification of GST-fusion proteins using glutathione (GSH) agarose beads is well documented and adaptable to a variety of scales, column formats and specific applications
No mutagenic, carcinogenic, or teratogenic effects were observed in the preclinical datasets published by the Zagreb group
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