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Semaglutide and Tirzepatide are two medications originally developed to treat diabetes but have since been found highly effective for weight loss

L-carnitine also plays a role by transporting fatty acids to the mitochondria

In addition to pharmacology, we used a chemogenetic approach to drive the activity of Glp1r -expressing neurons in the OB

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Twice-weekly schedules require more cognitive load and are harder to sustain over months