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One troubling side effect of the use of DPP4 inhibitors is severe joint pain, so much so that the US FDA issued a Drug Safety Communication warning of this problem

539 Results from several Phase III clinical trials (ORION-9/10/11, NCT03397121, NCT03399370, and NCT03400800) have shown that subcutaneous injections of inclisiran every 6 months considerably reduce LDL-C levels by 4852%, demonstrating sustained efficacy and good tolerability

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Tirzepatide is given once a week as an injection under the skin, with the help of a prefilled, single-dose pen that is designed for self-administration