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The dominant reasons, documented across multiple 2025 real-world studies, are: cost and insurance denials (47.6% of discontinuations), intolerance of GI side effects (14.6%), and supply shortages (11.8%)
Orlistat Drug monograph BNF/NICE
The product is manufactured at an FDA-verified facility
Moderate alcohol consumption may be acceptable, but excessive alcohol can increase the risk of hypoglycemia and worsen gastrointestinal side effects
Safe Effective Possibly even protective in acute disease As the global burden of diabetes continues to rise, insights like this help guide better, more confident prescribing
Another trial demonstrated that nearly one-third of the participants lost more than 20% of their body weight
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