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Pregnancy and breastfeeding are also contraindicated due to a lack of safety data for systemic use in these populations
Caroline Apovian, co-director of the Center for Weight Management and Wellness at the Brigham and Women's Hospital in Boston, warned that use of these medications strictly for weight loss is causing less availability for "underserved" diabetic patients whose lives are at risk without the drugs
First-generation agents looked riskier in the raw numbers, but dose was the stronger signal after adjustment
They were also less likely to experience a documented opioid poisoning event over the study window, with 7% having such an event, versus 16% for those without a prescription (see Figure below)
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