apart from accounting for the reduced melatonin levels reported in ASD, abnormal pineal metabolism of N, N-dimethyltryptamine (DMT) - a breakdown product of the trace amine tryptamine and thought to act via both TAARs and serotonin 2 A receptor (5-HT 2A R) - may be responsible for DMT accumulation, which in turn results in abnormal neurogenesis, including the aberrant synaptic organisation characteristic of ASD (Shomrat and Nesher 2019)
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