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One of the most commonly used experimental models of IBD is the administration of an enema containing the contact-sensitizing allergen trinitrobenzenesulfonic acid (TNBS) in ethanol resulting in the development of macroscopic, histologic, and biochemical alterations that are well-characterized (Rachmilewitz et al, 1989

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Consequently, people who follow vegetarian or vegan diets are at greater risk of insufficient intake, as are older adults, who are more likely to have reduced gastric acid production affecting B12 absorption

Shorter shelf life

Injection works faster than the oral supplement

In alignment with Nauck et al