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65 years), baseline eGFR ( 40%), treatment with 10 mg empagliflozin for a median time of 26.2 months reduced the risk of a composite of CV death or hospitalization for HF by 21%, and effect which was mainly related to a 29% lower risk of hospitalization for HF
doi: 10.1161/ATVBAHA.115.305380 117 KnudsenLBLauJ
The risk goes up in certain situations
Contrariamente ai trials LEADER e SCALE, nel trial LIRA-RENAL liraglutide si dimostrata inefficace nel migliorare gli outcomes renali su un campione di 279 pazienti diabetici con IRC moderata (eGFR 30-59 ml/min/1,73m 2 ): gli autori non hanno infatti riscontrato alcuna differenza in termini di eGFR e di UACR rispetto al placebo dopo 26 settimane di trattamento [40]
Orforglipron also produced significant but somewhat lower weight loss than oral semaglutide
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