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It can be highly activated by various stress stimuli, where it is required for the re-folding of damaged and unfolded proteins generated under stress 43

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Most rodent studies used: 10 micrograms/kg 100 micrograms/kg Administration routes varied by study: Intraperitoneal injection Subcutaneous injection Oral administration in drinking water Example reference: Sikiric et al., 2018 These dosages reflect controlled laboratory conditions and are not generalised outside experimental models