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Particularly, xCT is essential for cell survival and the maintenance of glutathione (GSH) homeostasis and has thus been identified as key target for anticancer therapy
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The corresponding Crystallographic Information File ( CIF ), generated from the refinement, was used to construct detailed visualizations using VESTA 3.5.8 software, as presented in Fig
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Our proposition is that the suboptimal glutathione levels associated with so many chronic diseases are not due to a cysteine undersupply but an impairment in one of the multiple control mechanisms of the GCL enzyme
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