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Acidic glutathione S-transferases of rat testis [PMID: 4052031] Laboratory literature summary: Acidic glutathione S-transferases of rat testis
Pharmacists must counsel patients on the presentation of EDKA, including nausea, vomiting, shortness of breath, lethargy, loss of appetite, fatigue, and abdominal pain
A meta-analysis of 113 RCTs comprising 33,167 patients in the GLP-1 RA cohort and 26,683 in the comparator cohort revealed no significant elevation in pancreatitis or pancreatic cancer risk relative to control groups (Mantel-Haenszel odds ratio [MH-OR] of 0.93 and 0.94, respectively), but identified a notable increase in cholelithiasis risk (MH-OR, 1.30) [58]
In a recent paper in The New England Journal of Medicine, physician Amanda Banks noted that the proportion of GLP-1 prescriptions written for people who were not diabetic, obese, or overweight increased from 4.5% in 2018 to 17% in 2023
The MHRA's Yellow Card scheme continues to monitor post-marketing safety data, including any reports of pancreatic malignancy
If patients do not tolerate a dose during dose escalation, consider delaying dose escalation
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