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Presented for research literature review only Ionescu M et al

Key Findings: Asian participants: 21.3% mean weight loss with CagriSema (similar to overall population) Safety profile consistent across ethnicities GI tolerability similar but potentially lower discontinuation rates in Asian populations Clinical Significance: Supports global applicability of cagrilintide-based therapies across diverse populations

Potential Benefits (preclinical) Fat metabolism: Animal models report reductions in fat mass while lean muscle is preserved [5] [6]

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It has additional benefits for conditions like chronic depression and pancreatitis