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The peptide sequence itself maintains sufficient homology to native GIP (42 amino acids) to activate GIP receptors with high affinity while incorporating specific amino acid substitutions that confer potent GLP-1 receptor agonism
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These concerns kept GIP on the back burner for years while GLP-1 took center stage in drug development
Use small meals, protein, hydration, and slower eating, and contact your clinician if symptoms become severe or persistent
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