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We need better subgroup analysis, better tolerability data, and better long-term follow-up

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The most common side effects with naltrexone are: Nausea Vomiting Headaches Fatigue Heightened Anxiety Abdominal Pain Dizziness Muscle pain Joint pain Constipation Diarrhea Appetite Loss Insomnia Sleep Disturbances Serious side effects that are much less likely include: Liver Damage Depression Allergic Reaction GLP-1 The side effects for GLP-1 medications are very similar to naltrexone