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Accessed 5 Sep 2023

This allows them to spend resources on a single significant development program, for one optimal injection device, which then requires minimal customization for each subsequent product line. Despite efforts to make better, safer, simpler injection devices, patient adherence is still a challenge associated with self-administration

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In the Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron produced mean body weight reductions of 7.5% (6 mg), 8.4% (12 mg), and 11.2% (36 mg) at 72 weeks, compared with 2.1% for placebo

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[8] In 2009, Topol worked with Gary and Mary West to create the West Wireless Health Institute, now called West Health Institute, to foster the use of digital tools in medical research and practice