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Type 1 diabetes is caused by the autoimmune destruction of the insulin-producing -cells of the pancreas, leading to an insufficient production of insulin

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Previous publications reported that TMAO was inhibited by antibiotic use, whose administration over an extended period has negative effects such as the development of clostridium colitis (Nie et al., 2018)

That's a fundamentally different proposition from administering a synthetic analog

Lethargy and reduced energy peak 24 hours post-dose, which is why nighttime administration is standard