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Relevant here, new chemical entity (NCE) exclusivity is earned whenever FDA approves a new medicine for the first time
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Multiple Lesions: Report the most complex procedure performed within the same vessel, regardless of the number of lesions treated
Huang H, Liu N, Yang C, et al
Nitric oxide synthases: regulation and function
This exception reinforces rather than undermines the central conclusion: economic feasibility emerges from molecular pharmacology, not from delivery ingenuity
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